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Isolation of vosamidines A-C demonstrates modest inhibition of a key kinase in a marine sponge, suggesting potential therapeutic applications.
Vosamidines A-C (1-3), three polycyclic 2-aminoimidazole alkaloids, were isolated from a marine calcareous sponge, Vosmaeropsis wilsoni. Their structures were determined by extensive analysis of spectroscopic and spectrometric data, along with ECD computational studies. Vosamidine A possesses a 6/5/5/5/6/15(6)(5)-fused ring system based on a unique pentacyclic core. Vosamidine B is an oxidized and ring rearranged derivative of 1. Vosamidine C possesses an unusual 5/5/6/5/5/8 hexacyclic ring system incorporating a thioether ring. Plausible biosynthetic pathways for 1-3 are proposed. Compounds 1 and 2 had modest inhibition in the oncogenic fusion protein kinase DNAJB1-PKAcα assay.
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Senadeera et al. (2026) studied this question.
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