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Phytochemical analysis uncovers novel trimeric alkaloids in Voacanga africana bark, highlighting potent antimycobacterial properties that lack cytotoxicity.
Voatriafricanines A and B ( 1 and 2 ), the first examples of vobasine-aspidosperma-aspidosperma monoterpene trisindole alkaloids, were isolated from the stem barks of Voacanga africana, guided by a molecular networking strategy. Their structures, including absolute configurations, were elucidated by spectroscopic methods and ECD calculations. Compounds 1 and 2 possess intramolecular hydrogen bonding, sufficiently robust to transfer homonuclear and heteronuclear magnetizations. Compound 1 exhibited potent antimycobacterial activity with no discernible cytotoxic activity.
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Fouotsa et al. (2021) studied this question.
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