Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis
Why the study?
Do obesity and metabolic health status independently affect the risk of coronary heart disease?
Population
pan-European individuals
Comparison
Obesity and metabolic unhealthiness (exposures) vs Lean and metabolically healthy individuals
Design
Cohort
Authors
Discussion
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Member takes
Implication
Metabolic health and BMI warrant separate CHD risk consideration; challenges metabolically healthy obesity concept yet remains hypothesis-generating.
Structured PICO
Do obesity and metabolic health status independently affect the risk of coronary heart disease?
P
Population
pan-European individuals
I
Intervention
Obesity and metabolic unhealthiness (exposures)
C
Comparator
Lean and metabolically healthy individuals
O
Outcome
Coronary heart disease (CHD)hard clinical
The study challenges the concept of 'metabolically healthy obesity', demonstrating that both obesity and poor metabolic health independently increase the risk of coronary heart disease.
Cite This Study
Lassale et al. (2017) studied this question.