Key result
Lifelong lower LDL-C linked to ~55% reduced CHD risk per mmol/L.
Why the study?
The association between long-term exposure to lower LDL-C beginning early in life and the risk of CHD has not been reliably quantified.
Does long-term exposure to lower LDL-C beginning early in life reduce the risk of coronary heart disease?
Meta-Analysis (n=312,321)
Mendelian randomization
Does long-term exposure to lower LDL-C beginning early in life reduce the risk of coronary heart disease?
Effect estimate: 54.5% reduction (95% CI 48.8% to 59.5%)
p-value: p=8.43 × 10(-19)
Prolonged exposure to lower LDL-C beginning early in life is associated with a 3-fold greater reduction in CHD risk per unit lower LDL-C compared to statin therapy started later in life.
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Supports assessing lifetime LDL-C exposure in CHD prevention; extends statin trials by confirming 3-fold greater benefit from early lowering.
Ference et al. (2012) conducted a meta-analysis in Coronary heart disease (n=312,321). Long-term exposure to lower LDL-C vs. Higher LDL-C was evaluated on Risk of coronary heart disease (54.5% reduction, 95% CI 48.8% to 59.5%, p=8.43 × 10(-19)). Long-term exposure to lower LDL-C beginning early in life was associated with a 54.5% (95% CI: 48.8% to 59.5%) reduction in CHD risk per 1 mmol/l lower LDL-C.
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