Key result
A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke, and coronary artery disease.
Population
200,000 individuals of European descent, with comparison data from >75,000 people of East Asian, South…
Design
Other
Authors
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Supports polygenic hypertension risk; leaves open whether this GRS improves clinical prediction or outcomes.
Observational (n=275,000)
Yes
The identification of 16 novel genetic loci associated with blood pressure provides new insights into the biological pathways of hypertension and potential therapeutic targets for cardiovascular disease prevention.
Ehret et al. (2011) conducted an observational in Blood pressure elevation and cardiovascular disease (n=275,000). Genetic risk score based on 29 genome-wide significant variants was evaluated on Blood pressure, hypertension, left ventricular wall thickness, stroke, coronary artery disease, and kidney disease. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke, and coronary artery disease.
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