Key result
Genome-wide meta-analysis identifies 8 novel genetic signals linked to blood pressure regulation.
Why the study?
Elevated blood pressure has a substantial genetic contribution and identifying genetic variation influencing blood pressure may reveal new pharmacological targets for hypertension treatment.
Meta-Analysis (n=378,376)
Yes
p-value: p=<5x10^-8
The discovery of novel genetic loci and genes associated with blood pressure regulation provides new potential pharmacological targets for the treatment of hypertension.
May nominate novel antihypertensive targets; leaves open clinical translation pending functional validation.
Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150,134 European ancestry individuals and sought significant evidence for independent replication in a further 228,245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9 and AKT2 , and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA . Combining large whole-blood gene expression resources totaling 12,607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in BP regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
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Wain et al. (2017) conducted a meta-analysis in Blood pressure (n=378,376). Genetic variants (SNPs) vs. Reference alleles was evaluated on Novel blood pressure loci associated with systolic blood pressure, diastolic blood pressure, or pulse pressure (p=<5x10^-8). A genome-wide association meta-analysis identified 8 novel genetic signals associated with blood pressure and 48 genes with robust evidence for involvement in blood pressure regulation.
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