October 1, 2017Circulation Cardiovascular GeneticsOpen Access

New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals

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Population

~475,000 individuals of European, South Asian, African, and Hispanic descent, including a subset of ~423,000…

Design

Meta-analysis

Discussion

Member takes

Implication

Expands BP genetic architecture; extends prior GWAS while leaving clinical translation open.

Structured PICO

Population

~475,000 individuals of European, South Asian, African, and Hispanic descent (pan-ancestry), including a subset of ~423,000 individuals of European descent (with 140,886 from the UK Biobank)

Intervention

77 single nucleotide variants (SNVs) previously showing suggestive evidence of association with blood pressure

Outcome

Association with systolic blood pressure, diastolic blood pressure, or pulse pressuresurrogate

This large-scale meta-analysis identified 4 novel genetic loci associated with blood pressure regulation, providing new candidate genes for potential follow-up.

Cite This Study

A 2017 study studied this question.

synapsesocial.com/papers/6a886a2b86ac178e8f609a01 https://doi.org/10.1161/circgenetics.117.001778

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New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals

Discussion

Member takes

Implication

Structured PICO

Cite This Study

New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider