What question did this study set out to answer?

To compare the efficacy of sublingual immunotherapy (SLIT) and antihistamines in managing allergic rhinitis (AR) symptoms and enhancing quality of life during Japanese cedar pollen dispersal seasons.

April 25, 2026The Journal of Medical Investigation0 citationsOpen Access

Comparison of the efficacy of sublingual immunotherapy and prophylactic treatment with antihistamines on allergic rhinitis symptoms and quality of life in small and large Japanese cedar pollen dispersal years

TFTatsuya Fujii SKSeiichiro Kamimura KIKeisuke Ishitani

Key Points

To compare the efficacy of sublingual immunotherapy (SLIT) and antihistamines in managing allergic rhinitis (AR) symptoms and enhancing quality of life during Japanese cedar pollen dispersal seasons.
Conducted over different dispersal years of Japanese cedar pollen
Compared symptom relief with SLIT and prophylactic antihistamine treatment
Measured quality of life improvements during high pollen periods.
SLIT demonstrated greater effectiveness in reducing allergic rhinitis symptoms compared to antihistamines during large JC pollen seasons
Improved quality of life was noted in patients receiving SLIT during these periods.

Abstract

These findings suggested that JC pollen SLIT was more effective in suppressing AR symptoms than prophylactic treatment with antihistamines, resulting in improved QOL during the large JC pollen dispersal season. J. Med. Invest. 73 : 55-61, February, 2026.

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