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July 29, 2021The Journal of Allergy and Clinical Immunology In PracticeOpen Access

Disease-Modifying Effect of Japanese Cedar Pollen Sublingual Immunotherapy Tablets

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Authors

SYSyuji YonekuraMGMinoru GotohSKShinya Kaneko

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Overview

Randomized trial demonstrates sustained symptom reduction from sublingual immunotherapy tablets in allergic rhinitis, indicating long-term disease modification after treatment cessation.

Key Points

  • To evaluate the disease-modifying efficacy and safety of Japanese cedar pollen sublingual immunotherapy tablets across 3 years of treatment and 2 years of post-treatment follow-up.
  • Conducted an interventional study in 1,042 patients aged 5–64 years with Japanese cedar pollinosis, initiating with a 15-month dose-finding phase.
  • Re-randomized 476 patients (240 placebo, 236 active 5,000 Japanese allergy units) into four arms (AA, AP, PA, PP) for an additional 18 months of treatment.
  • Evaluated total nasal symptom and medication scores (TNSMS) during peak pollen seasons throughout 3 years of treatment and 2 years of post-cessation observation.
  • Patients receiving continuous active therapy (AA group) achieved a 46.3% relative reduction in TNSMS versus placebo (PP group) during the third treatment season (P < .001).
  • Sustained disease-modifying effects persisted off-treatment in the AA group, with relative TNSMS reductions of 45.3% in season 4 and 34.0% in season 5 versus the PP group (both P < .001).
  • Reported adverse drug reactions were predominantly mild and localized to the site of administration.

Cite This Study

Yonekura et al. (2021) studied this question.

synapsesocial.com/papers/6a707d2775498292b709ec49https://doi.org/10.1016/j.jaip.2021.06.060
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real‐Life Safety of Japanese Cedar Pollen Sublingual Immunotherapy Tablets: A Post‐Marketing Survey2026 · 3 citations
  2. 2Comparison of the efficacy of sublingual immunotherapy and prophylactic treatment with antihistamines on allergic rhinitis symptoms and quality of life in small and large Japanese cedar pollen dispersal years2026
  3. 3Sublingual immunotherapy for Japanese cedar pollinosis: current status in Japan2012
  4. 4Antidepressant initiation after sublingual immunotherapy in Japanese cedar pollinosis: a real-world propensity score-matched cohort study2026
  5. 5Maintenance dose and Japanese cedar pollen-specific immunoglobulin E changes during pediatric Japanese cedar pollen subcutaneous immunotherapy2026