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September 2, 2026Current Medical Research and Opinion

Antidepressant initiation after sublingual immunotherapy in Japanese cedar pollinosis: a real-world propensity score-matched cohort study

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Authors

RMRie MatsushitaSTSachiko Tanaka‐MizunoKKKoji Kawakami

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Overview

Retrospective cohort study finds no link between sublingual immunotherapy and antidepressant initiation in Japanese cedar pollinosis, suggesting allergy treatments do not influence depression risk.

Key Points

  • To determine whether sublingual immunotherapy for Japanese cedar pollinosis is associated with the subsequent initiation of antidepressant prescriptions in clinical practice.
  • Conducted a retrospective cohort study using a nationwide administrative claims database in Japan from 2014 to 2021.
  • Identified adult patients with Japanese cedar pollinosis and categorized them into sublingual immunotherapy (SLIT) users (N=4,126) and non-users (N=88,455) using a new-user design.
  • Applied propensity score matching on baseline demographics, insurance type, and medical history to create 3,991 balanced patient pairs to assess antidepressant initiation using hazard ratios.
  • Prior to matching, crude initiation rates of antidepressants were 5.0 per 1,000 person-years among SLIT users compared to 2.9 per 1,000 person-years among non-users.
  • In the propensity-matched cohort, SLIT use showed no statistically significant association with antidepressant initiation (HR = 1.11, 95% CI = 0.73–1.69).
  • Kaplan-Meier survival analysis demonstrated no significant difference in antidepressant-free survival between SLIT users and matched non-users.

Cite This Study

Matsushita et al. (2026) studied this question.

synapsesocial.com/papers/6a97e237c562ede874ec6344https://doi.org/10.1080/03007995.2026.2722388
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disease-Modifying Effect of Japanese Cedar Pollen Sublingual Immunotherapy Tablets2021 · 64 citations
  2. 2Comparison of the efficacy of sublingual immunotherapy and prophylactic treatment with antihistamines on allergic rhinitis symptoms and quality of life in small and large Japanese cedar pollen dispersal years2026
  3. 3Sublingual immunotherapy for Japanese cedar pollinosis: current status in Japan2012
  4. 4Effect of initiation treatment timing on efficacy of Artemisia Annua sublingual immunotherapy in patients with allergic rhinitis2026
  5. 5Real-world use of sublingual immunotherapy and shared decisions in French observational study PRACTIS2026