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April 25, 2026Drug Design Development and TherapyOpen Access

Atorvastatin Attenuates Vancomycin-Induced Nephrotoxicity via PPARα-Associated Regulation of SLC Transporters

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Authors

KLKexin LinDalian Medical UniversityTLTingyu LiDalian Medical UniversityXKXiaorui KongDalian Medical University

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Implication

Preclinical study demonstrates atorvastatin’s protective effects against vancomycin nephrotoxicity, highlighting a new treatment strategy.

Key Points

  • To determine if atorvastatin can mitigate vancomycin-induced nephrotoxicity and explore the underlying mechanisms.
  • Evaluated the effects of atorvastatin in male C57BL/6 mice and HK-2 cells.
  • Assessed renal function, histopathology, inflammation, oxidative stress, and apoptosis.
  • Conducted transcriptome sequencing of renal tissue for mechanistic insights.
  • Atorvastatin significantly improved vancomycin-induced renal dysfunction in mice (p<0.05).
  • It reduced inflammatory cytokines and enhanced antioxidant capacity in the kidneys.
  • In HK-2 cells, atorvastatin increased cell viability and decreased apoptosis and ROS production.

Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69ec5a2588ba6daa22dabb68https://doi.org/10.2147/dddt.s571916
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sorting out the roles of PPAR in energy metabolism and vascular homeostasis2006 · 965 citations
  2. 2Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways2014 · 52 citations