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December 11, 2018Journal of Cardiovascular Pharmacology

Atorvastatin improves cardiac function and reduces myocardial fibrosis in doxorubicin-induced HF rats.

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Why the study?

Statins demonstrate anti-heart failure effects, but the specific mechanism remains unclear.

Does atorvastatin improve cardiac dysfunction in a rat model of doxorubicin-induced heart failure?

Population

Doxorubicin-induced heart failure rat model

Comparison

Low-dose atorvastatin vs high-dose atorvastatin vs saline

Design

Preclinical animal study

Follow-up

4 weeks

Key result

Atorvastatin improved cardiac function and reduced myocardial fibrosis and apoptosis in a rat model of doxorubicin-induced heart failure by modulating Hsp70, p-Akt, p-ERK, and p-JNK signaling.

Authors

GGGe GaoSJShi-liang JiangLGLili Ge

Discussion

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Member takes

Overview

Atorvastatin attenuates doxorubicin-induced HF in rats; leaves open clinical translation and mechanism validation in humans.

Structured PICO

Does atorvastatin improve cardiac dysfunction in a rat model of doxorubicin-induced heart failure?

P
Population
Rats with doxorubicin-induced heart failure treated with low-dose atorvastatin, high-dose atorvastatin, or saline for 4 weeks.
I
Intervention
Low-dose or high-dose atorvastatin for 4 weeks
C
Comparator
Saline for 4 weeks
O
Outcome
Cardiac function (left ventricular ejection fraction, fractional shortening, left ventricular end-diastolic diameter, left ventricular posterior wall thickness)surrogate

Atorvastatin protects cardiac function in a rat model of doxorubicin-induced heart failure by modulating Hsp70, Akt, and MAPK signaling pathways to reduce myocardial fibrosis and apoptosis.

Cite This Study

Gao et al. (2018) studied Doxorubicin-induced heart failure. Atorvastatin vs. saline was evaluated on Cardiac function (LVEF, fractional shortening, LVEDD, LVPWT) and myocardial injury. Atorvastatin improved cardiac function and reduced myocardial fibrosis and apoptosis in a rat model of doxorubicin-induced heart failure by modulating Hsp70, p-Akt, p-ERK, and p-JNK signaling.

synapsesocial.com/papers/6aa69972bc2c7db7488e68afhttps://doi.org/10.1097/fjc.0000000000000646
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atorvastatin improves cardiac function and remodeling in chronic non-ischemic heart failure: A clinical and pre-clinical study2014 · 8 citations
  2. 2Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats2014 · 57 citations
  3. 3Atorvastatin Inhibits Myocardial Cell Apoptosis in a Rat Model with Post-myocardial Infarction Heart Failure by Downregulating ER Stress Response2011 · 101 citations
  4. 4Pretreatment with Statin Attenuates the Cardiotoxicity of Doxorubicin in Mice2009 · 207 citations
  5. 5Atorvastatin Attenuates Myocardial Hypertrophy in Spontaneously Hypertensive Rats via the C/EBPβ/PGC-1α/UCP3 Pathway2018 · 17 citations