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June 5, 2013Chinese Medical JournalOpen Access

Atorvastatin significantly reduced fibrotic tissue hyperplasia, decreased type I and III collagen and TIMP-2 expression, and increased the MMP-2/TIMP-2 ratio compared to the MI group.

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Why the study?

Does atorvastatin reduce myocardial fibrosis in a rat model of post-myocardial infarction heart failure?

Population

Rat model of heart failure established by left anterior descending coronary artery ligation, and primary rat…

Comparison

Atorvastatin vs Myocardial infarction model without…

Design

Preclinical

Authors

ZAZhe AnGYGuang YangYHYuquan He

Discussion

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Overview

Hypothesis-generating for atorvastatin in post-MI fibrosis; clinical translation and human outcomes remain untested.

Structured PICO

Does atorvastatin reduce myocardial fibrosis in a rat model of post-myocardial infarction heart failure?

P
Population
Rat model of heart failure established by left anterior descending coronary artery ligation, and primary rat cardiac fibroblasts
I
Intervention
Atorvastatin
C
Comparator
Myocardial infarction model (MI) without atorvastatin, and sham operation (SO)
O
Outcome
Myocardial fibrosis (histological changes), expression of type I and III collagen, MMP-2, and TIMP-2surrogate

Atorvastatin reduces myocardial fibrosis in a post-MI heart failure rat model by increasing the MMP-2/TIMP-2 ratio and inhibiting fibroblast proliferation.

Cite This Study

An et al. (2013) studied this question.

synapsesocial.com/papers/6a21436ca2a97f3a085ae049https://doi.org/10.3760/cma.j.issn.0366-6999.20123223
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism2016 · 35 citations
  2. 2<i>IN VITRO</i> INHIBITORY EFFECTS OF ATORVASTATIN ON CARDIAC FIBROBLASTS: IMPLICATIONS FOR VENTRICULAR REMODELLING2005 · 62 citations
  3. 3Atorvastatin Inhibits Myocardial Cell Apoptosis in a Rat Model with Post-myocardial Infarction Heart Failure by Downregulating ER Stress Response2011 · 101 citations
  4. 4Inactivation of Notch1-TGF-β-Smads Signaling Pathway by Atorvastatin Improves Cardiac Function and Hemodynamic Performance in Acute Myocardial Infarction Rats2025 · 3 citations
  5. 5Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats2014 · 57 citations