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November 23, 2016PLoS ONEOpen Access

Atorvastatin significantly reduced end-diastolic volume, fibrotic content, and myocyte cross-sectional area compared to control, and modulated collagen metabolism and inflammatory proteins.

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Why the study?

Does atorvastatin improve ventricular remodeling and collagen metabolism after myocardial infarction in rats?

Population

Male Wistar rats with induced myocardial infarction by left anterior descending coronary artery ligation

Comparison

Atorvastatin 10 mg/kg/day for 4 weeks vs Saline solution for 4 weeks and sham surgery…

Design

Preclinical, Animals were randomized into three groups

Follow-up

4 weeks

Authors

KRKarla ReichertHCHelison Rafael Pereira do CarmoATAnali Galluce Torina

Discussion

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Overview

May attenuate post-MI remodeling in rats; hypothesis-generating and leaves open clinical translation.

Structured PICO

Does atorvastatin improve ventricular remodeling and collagen metabolism after myocardial infarction in rats?

P
Population
Male Wistar rats with induced myocardial infarction by left anterior descending coronary artery (LAD) ligation (n=65)
I
Intervention
Atorvastatin 10 mg/kg/day for 4 weeks
C
Comparator
Saline solution for 4 weeks (control group) and sham surgery without LAD ligation
O
Outcome
Ventricular remodeling and collagen metabolism (assessed by hemodynamics, histology for fibrosis and collagen deposition, myocyte cross-sectional area, and protein expression)surrogate

In a rat model of myocardial infarction, atorvastatin attenuated ventricular dysfunction, fibrosis, and hypertrophy, suggesting a role in limiting adverse ventricular remodeling.

Cite This Study

Reichert et al. (2016) studied this question.

synapsesocial.com/papers/6a21436ca2a97f3a085ae03ehttps://doi.org/10.1371/journal.pone.0166845
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atorvastatin Therapy during the Peri-Infarct Period Attenuates Left Ventricular Dysfunction and Remodeling after Myocardial Infarction2011 · 22 citations
  2. 2Atorvastatin reduces myocardial fibrosis in a rat model with post-myocardial infarction heart failure by increasing the matrix metalloproteinase-2/tissue matrix metalloproteinase inhibitor-2 ratio2013 · 16 citations
  3. 3Inactivation of Notch1-TGF-β-Smads Signaling Pathway by Atorvastatin Improves Cardiac Function and Hemodynamic Performance in Acute Myocardial Infarction Rats2025 · 3 citations
  4. 4Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction2008 · 55 citations
  5. 5<i>IN VITRO</i> INHIBITORY EFFECTS OF ATORVASTATIN ON CARDIAC FIBROBLASTS: IMPLICATIONS FOR VENTRICULAR REMODELLING2005 · 62 citations