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September 28, 2011PLoS ONEOpen Access

Atorvastatin therapy during the peri-infarct period significantly improved left ventricular ejection fraction (34.16% vs 24.30%, p<0.05) and limited adverse remodeling following myocardial infarction in rats.

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Why the study?

Does atorvastatin therapy during the peri-infarct period improve left ventricular function and attenuate remodeling after myocardial infarction in a rat model?

Population

40 Female Fischer 344 rats subjected to permanent coronary occlusion.

Comparison

Oral atorvastatin 10 mg/kg/d by gavage daily for… vs Equivalent volume of vehicle daily for 7 weeks.

Design

Preclinical, Echocardiographic images analyzed off-line by a single blinded…

Follow-up

4 weeks after myocardial infarction

Key result

Atorvastatin therapy during the peri-infarct period significantly improved left ventricular ejection fraction (34.16% vs 24.30%, p<0.05) and limited adverse remodeling following myocardial infarction in rats.

Authors

XTXian‐Liang TangSSSantosh K. SanganalmathHSHiroshi Sato

Discussion

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Member takes

Overview

Hypothesis-generating for peri-infarct atorvastatin post-MI; leaves open translation to human practice.

Structured PICO

Does atorvastatin therapy during the peri-infarct period improve left ventricular function and attenuate remodeling after myocardial infarction in a rat model?

P
Population
40 Female Fischer 344 rats (age 10-12 wk; body wt 175-200 g) subjected to permanent coronary occlusion (myocardial infarction model).
I
Intervention
Oral atorvastatin 10 mg/kg/d by gavage daily for 7 weeks (starting 3 weeks before and continuing for 4 weeks after myocardial infarction).
C
Comparator
Equivalent volume of vehicle (water) daily for 7 weeks (3 weeks before and 4 weeks after myocardial infarction).
O
Outcome
Left ventricular function (LVEF, FAC) and remodeling (LVEDV, LVESD, LVEDD) assessed by echocardiography at 4 weeks after myocardial infarction.surrogate

Main Result

Absolute Event Rate: 34.16% vs 24.3%

p-value: p=<0.05

In a rat model of myocardial infarction, peri-infarct atorvastatin therapy significantly improved left ventricular function and reduced adverse remodeling, fibrosis, and apoptosis, independent of infarct size.

Limitations

  • Lack of early reperfusion in the experimental model (permanent coronary occlusion)
  • Inability to determine if antiapoptotic effects were direct or secondary to improved LV function
  • Exact mechanisms, minimal effective dose, and minimal duration of treatment need further elucidation
  • Lack of early reperfusion in the experimental model (permanent occlusion)
  • Exact mechanisms of protective effect need further elucidation
  • Minimal effective dose and duration of treatment required are unknown

Cite This Study

Tang et al. (2011) studied Myocardial infarction (n=40). Atorvastatin vs. Vehicle (water) was evaluated on Left ventricular ejection fraction (LVEF) at 4 weeks (p=<0.05). Atorvastatin therapy during the peri-infarct period significantly improved left ventricular ejection fraction (34.16% vs 24.30%, p<0.05) and limited adverse remodeling following myocardial infarction in rats.

synapsesocial.com/papers/6a13ddae3f92ec2dd7598060https://doi.org/10.1371/journal.pone.0025320
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atorvastatin Improves Ventricular Remodeling after Myocardial Infarction by Interfering with Collagen Metabolism2016 · 35 citations
  2. 2Evaluation of effect of atorvastatin on left ventricular systolic function in rats with myocardial infarction via 2D-STI technique2018 · 3 citations
  3. 3Intravenous Statin Administration During Myocardial Infarction Compared With Oral Post-Infarct Administration2020 · 52 citations
  4. 4Early statin treatment prior to primary PCI for acute myocardial infarction: REPERATOR, a randomized placebo‐controlled pilot trial2012 · 51 citations
  5. 5Atorvastatin administered before myocardial infarction in rats improves contractility irrespective of metabolic changes2014 · 7 citations