Key result
Atorvastatin treatment pre- and post-myocardial infarction in rats improved left ventricular fractional shortening after 48 hours (~60% higher vs vehicle, P=0.036) but did not increase GLUT4 expression.
Why the study?
Does atorvastatin treatment pre- and post-myocardial infarction improve cardiovascular function and alter GLUT4 expression in Wistar-Kyoto rats?
Population
Wistar-Kyoto rats undergoing coronary artery occlusion surgery (myocardial infarction) or sham surgery
Comparison
Atorvastatin 20 mg/kg for 14 days before surgery… vs Vehicle
Design
Preclinical
Follow-up
7 days
Authors
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Transient post-MI contractility gain in rats without GLUT4 increase; hypothesis-generating and requires human validation before clinical consideration.
Does atorvastatin treatment pre- and post-myocardial infarction improve cardiovascular function and alter GLUT4 expression in Wistar-Kyoto rats?
p-value: p=0.036
Atorvastatin administered before and after myocardial infarction in rats transiently improves myocardial contractility at 48 hours without increasing GLUT4 expression.
Lehnen et al. (2014) studied Myocardial infarction. Atorvastatin vs. Vehicle was evaluated on Left ventricular fractional shortening after 48 h (p=0.036). Atorvastatin treatment pre- and post-myocardial infarction in rats improved left ventricular fractional shortening after 48 hours (~60% higher vs vehicle, P=0.036) but did not increase GLUT4 expression.
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