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May 15, 2012Cardiovascular TherapeuticsOpen Access

Effects of Acute and Chronic Atorvastatin on Cardioprotection of Ischemic Postconditioning in Isolated Rat Hearts

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Why the study?

Does acute or chronic atorvastatin treatment affect the cardioprotective effects of ischemic postconditioning in isolated rat hearts?

Population

Isolated rat hearts

Comparison

Acute or chronic atorvastatin treatment combined… vs Ischemic postconditioning (Ipost) alone or control

Design

Preclinical

Authors

YFYing FanSYShusen YangYCYang Cao

Discussion

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Overview

Caution advised for Ipost in chronic statin users; leaves open translation from rat models and requires clinical validation.

Structured PICO

Does acute or chronic atorvastatin treatment affect the cardioprotective effects of ischemic postconditioning in isolated rat hearts?

P
Population
Isolated rat hearts
I
Intervention
Acute or chronic atorvastatin treatment combined with ischemic postconditioning (Ipost)
C
Comparator
Ischemic postconditioning (Ipost) alone or control
O
Outcome
Infarct size and contractile dysfunction during reperfusionsurrogate

Chronic atorvastatin treatment may interfere with the cardioprotective effects of ischemic postconditioning by inhibiting Akt and eNOS activity, suggesting caution when applying Ipost in patients on chronic statin therapy.

Cite This Study

Fan et al. (2012) studied this question.

synapsesocial.com/papers/6a82b28d9192075d3cd4b020https://doi.org/10.1111/j.1755-5922.2012.00318.x
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