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January 10, 2009Cardiovascular Research

Treatment with atorvastatin partially protects the rat heart from harmful catecholamine effects

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Why the study?

Does atorvastatin protect the rat heart from the harmful effects of chronic isoprenaline infusion?

Population

Rats subjected to restraint stress and isoprenaline or NaCl infusion

Comparison

Atorvastatin via gavage for 14 days vs H2O via gavage for 14 days

Design

Preclinical

Follow-up

14 days

Authors

ASAriane SchmechelMGMichael GrimmAEAli El‐Armouche

Discussion

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Overview

May indicate cardioprotection in this rat model; hypothesis-generating and should not change clinical practice.

Structured PICO

Does atorvastatin protect the rat heart from the harmful effects of chronic isoprenaline infusion?

P
Population
Rats subjected to restraint stress and isoprenaline or NaCl infusion
I
Intervention
Atorvastatin (1 or 10 mg/kg/day) via gavage for 14 days
C
Comparator
H2O via gavage for 14 days
O
Outcome
Heart-to-body weight ratio (HW/BW), ANP mRNA levels, and left atrial contractile functionsurrogate

Atorvastatin partially protects the rat heart from catecholamine-induced hypertrophy and contractile dysfunction, likely via translocation of G proteins to the cytosol.

Cite This Study

Schmechel et al. (2009) studied this question.

synapsesocial.com/papers/6a907ec34aebf474cb342689https://doi.org/10.1093/cvr/cvp005
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Also Consider

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