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January 1, 2011International Journal of Medical SciencesOpen Access

Atorvastatin significantly decreased myocardial cell apoptosis and improved hemodynamic parameters in a rat model of post-myocardial infarction heart failure by downregulating ER stress response proteins.

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Why the study?

Does atorvastatin reduce myocardial cell apoptosis and ER stress in a rat model of post-myocardial infarction heart failure?

Population

38 female Wistar rats with heart failure induced by left anterior descending coronary artery ligation, and…

Comparison

Atorvastatin 10 mg/kg/d for 4 weeks in vivo… vs Untreated heart failure model and sham-operated…

Design

Preclinical, randomly divided

Follow-up

8 weeks post-surgery (4 weeks of treatment)

Key result

Atorvastatin significantly decreased myocardial cell apoptosis and improved hemodynamic parameters in a rat model of post-myocardial infarction heart failure by downregulating ER stress response proteins.

Authors

XSXian Jing SongCYChun YangBLBin Liu

Discussion

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Member takes

Overview

Hypothesis-generating in rat post-MI HF; leaves open translation to human therapy and should not change practice.

Structured PICO

Does atorvastatin reduce myocardial cell apoptosis and ER stress in a rat model of post-myocardial infarction heart failure?

P
Population
38 female Wistar rats with heart failure induced by myocardial infarction, treated with atorvastatin for 4 weeks.
I
Intervention
Atorvastatin 10 mg/kg/d for 4 weeks (started 4 weeks post-MI) in vivo; 10^-5 M atorvastatin in vitro.
C
Comparator
Untreated heart failure model (LAD ligation) and sham-operated control.
O
Outcome
Myocardial cell apoptosis and expression of ER stress markers (GRP78, caspase-12, CHOP).surrogate

Main Result

p-value: p=<0.05

Atorvastatin protects against post-myocardial infarction heart failure in rats by inhibiting myocardial cell apoptosis and downregulating the endoplasmic reticulum stress response.

Limitations

  • The association between ERSR and apoptosis has not been fully demonstrated in this study.

Cite This Study

Song et al. (2011) studied Heart failure after myocardial infarction (n=38). Atorvastatin vs. Untreated heart failure model and sham surgery was evaluated on Myocardial cell apoptosis and ER stress response (p=<0.05). Atorvastatin significantly decreased myocardial cell apoptosis and improved hemodynamic parameters in a rat model of post-myocardial infarction heart failure by downregulating ER stress response proteins.

synapsesocial.com/papers/6a995c95d2b4da1de4bd5a99https://doi.org/10.7150/ijms.8.564
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Also Consider

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