Why the study?
Atorvastatin has reported cardioprotective effects, but the mechanism by which it attenuates cardiac hypertrophy and inhibits cardiac failure remains unclear.
Does atorvastatin reduce cardiac hypertrophy and cardiomyocyte apoptosis in preclinical models of hypertrophy?
Population
Rats with TAC-induced cardiac hypertrophy and cardiomyocytes treated with Ang II
Comparison
Atorvastatin treatment vs control
Design
Preclinical animal and cell study
Authors
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Hypothesis-generating in rat TAC model; leaves open clinical translation to human hypertrophy or heart failure.
Does atorvastatin reduce cardiac hypertrophy and cardiomyocyte apoptosis in preclinical models of hypertrophy?
Atorvastatin attenuates cardiac hypertrophy and apoptosis through the AMPK/miR-143-3p/Bcl2 axis, providing a molecular mechanism for its cardioprotective effects in heart failure models.
Sun et al. (2019) studied this question.
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