Key result
Atorvastatin significantly reduced the heart/body weight ratio from 8.69 mg/g to 6.45 mg/g (p<0.001) in mice with pressure overload, ameliorating cardiac remodeling.
Why the study?
Does atorvastatin improve cardiac remodeling in mice with pressure overload?
Population
Male C57BL/6J mice with transverse aortic constriction (TAC) and cultured neonatal rat cardiomyocytes
Comparison
Atorvastatin (5 mg/kg/day) orally administered vs Vehicle
Design
Preclinical
Follow-up
4 weeks
Authors
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Atorvastatin attenuated remodeling via EGFR in TAC mice; leaves open human translation and requires clinical trials.
Does atorvastatin improve cardiac remodeling in mice with pressure overload?
Absolute Event Rate: 6.45% vs 8.69%
p-value: p=<0.001
Atorvastatin ameliorates cardiac remodeling in mice with pressure overload, likely via inhibition of the EGFR signaling pathway.
Liao et al. (2008) studied Cardiac remodeling with pressure overload (n=46). Atorvastatin vs. Vehicle was evaluated on Heart/body weight ratio (p=<0.001). Atorvastatin significantly reduced the heart/body weight ratio from 8.69 mg/g to 6.45 mg/g (p<0.001) in mice with pressure overload, ameliorating cardiac remodeling.
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