Key result
Early atorvastatin prevents LV remodeling in hypertensive rats, reducing LV weight ratio ~15% vs control.
Why the study?
Statins improve left ventricular remodeling in spontaneously hypertensive rats, but the effects of early-stage atorvastatin administration and underlying mechanisms were not fully investigated.
Does atorvastatin prevent left ventricular remodeling in spontaneously hypertensive rats?
Population
16 male 8-week-old spontaneously hypertensive rats and age-matched male Wistar-Kyoto rats
Comparison
Atorvastatin vs distilled water
Design
Randomized preclinical study
Follow-up
12 weeks
Authors
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No immediate clinical implications in hypertension; leaves open translation of early atorvastatin effects to human LV remodeling.
Does atorvastatin prevent left ventricular remodeling in spontaneously hypertensive rats?
Absolute Event Rate: 4% vs 4.7%
p-value: p=<0.05
Early-stage administration of atorvastatin prevents left ventricular remodeling in spontaneously hypertensive rats, potentially by inhibiting myocardial CTGF expression and inducing cardiomyocyte apoptosis.
Zhao et al. (2010) studied Hypertension and Left Ventricular Remodeling (n=24). Atorvastatin vs. Distilled water was evaluated on Left ventricular weight to body weight ratio (mg/g) (p=<0.05). Early-stage administration of atorvastatin significantly prevented left ventricular remodeling in spontaneously hypertensive rats, reducing the LV weight to body weight ratio compared to control (4.0 vs 4.7 mg/g, P < 0.05).
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