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January 1, 2018Cellular Physiology and BiochemistryOpen Access

Atorvastatin attenuated LV wall thickness and interstitial fibrosis in SHR without significantly reducing mean arterial pressure compared to water-treated SHR, while reversing changes in C/EBPβ, PGC-1α, and UCP3 expression.

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Why the study?

Does atorvastatin attenuate myocardial hypertrophy and remodeling in spontaneously hypertensive rats?

Population

24 male, age-matched rats (8 Wistar-Kyoto [WKY] controls, 16 spontaneously hypertensive rats [SHR])

Comparison

Atorvastatin 10 mg/kg once daily by oral gavage… vs Equal quantity distilled water by oral gavage…

Design

Preclinical, Randomly divided into three groups

Follow-up

6 weeks

Authors

YCYintao ChenTen Chen HospitalYCYe Rim ChangAnhui Medical UniversityNZNaijin ZhangTianjin University of Traditional Chinese Medicine

Discussion

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Overview

May suggest BP-independent anti-remodeling effects in hypertensive rats; leaves open human translation and requires prospective trials.

Structured PICO

Does atorvastatin attenuate myocardial hypertrophy and remodeling in spontaneously hypertensive rats?

P
Population
24 male, age-matched rats (8 Wistar-Kyoto [WKY] controls, 16 spontaneously hypertensive rats [SHR])
I
Intervention
Atorvastatin 10 mg/kg once daily by oral gavage for 6 weeks
C
Comparator
Equal quantity distilled water by oral gavage for 6 weeks
O
Outcome
Myocardial hypertrophy and remodeling (assessed by echocardiography, histology, and protein expression)surrogate

Atorvastatin attenuates hypertension-induced myocardial hypertrophy and remodeling in rats independently of blood pressure reduction, likely via the C/EBPβ/PGC-1α/UCP3 signaling pathway.

Cite This Study

Chen et al. (2018) studied this question.

synapsesocial.com/papers/6a7cfa885ea1f309fbcd909bhttps://doi.org/10.1159/000488832
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atorvastatin Prevents Left Ventricular Remodeling in Spontaneously Hypertensive Rats2010 · 8 citations
  2. 2Atorvastatin attenuates cardiac hypertrophy through AMPK/miR-143-3p/Bcl2 axis2019 · 11 citations
  3. 3Atorvastatin Inhibits Myocardial Cell Apoptosis in a Rat Model with Post-myocardial Infarction Heart Failure by Downregulating ER Stress Response2011 · 101 citations
  4. 4Effect of Atorvastatin on Expression of Peroxisome Proliferator-activated Receptor Beta/delta in Angiotensin II-induced Hypertrophic Myocardial Cells In Vitro2015 · 5 citations
  5. 5Prevention of Cardiac Hypertrophy by Atorvastatin in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy2005 · 160 citations