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March 15, 2018International Journal of Molecular MedicineOpen Access

Cardioprotective effect of rosuvastatin against isoproterenol-induced myocardial infarction injury in rats

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Why the study?

Does rosuvastatin reduce myocardial infarction injury in an isoproterenol-induced rat model?

Population

Rat model of myocardial infarction injury induced by isoproterenol (ISO) for 2 consecutive days

Comparison

Rosuvastatin administered for 8 weeks vs Isoproterenol-induced rats without rosuvastatin

Design

Preclinical

Follow-up

8 weeks

Authors

YYYing YuCentral China Normal UniversityLJLin JinChinese Academy of Medical Sciences & Peking Union Medical CollegeYZYamin ZhuangUniversity of Utah

Discussion

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Member takes

Overview

No immediate clinical implications for MI; leaves open translation of rodent cardioprotection data.

Structured PICO

Does rosuvastatin reduce myocardial infarction injury in an isoproterenol-induced rat model?

P
Population
Rat model of myocardial infarction injury induced by isoproterenol (ISO) for 2 consecutive days
I
Intervention
Rosuvastatin administered for 8 weeks
C
Comparator
Isoproterenol-induced rats without rosuvastatin (implied control)
O
Outcome
Myocardial infarct size, myocardial injury marker enzymes (AST, ALT, CK-MB, LDH), oxidative stress markers, histological changes, and NLRP3 inflammasome levelssurrogate

In a rat model, rosuvastatin alleviates isoproterenol-induced myocardial infarction injury by attenuating oxidative stress and inflammation via NLRP3 inflammasome inhibition.

Cite This Study

Yu et al. (2018) studied this question.

synapsesocial.com/papers/6a70460c35aa2c282ce19261https://doi.org/10.3892/ijmm.2018.3572
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardioprotective potential of Rosuvastatin against isoproterenol induced cardiac dysfunction and hypertrophy in the experimental model of rodents2023 · 3 citations
  2. 2Rosuvastatin inhibits inflammatory response and resists fibrosis after myocardial infarction.2018 · 20 citations
  3. 3Protective effects of low‐dose rosuvastatin on isoproterenol‐induced chronic heart failure in rats by regulation of <scp>DDAH</scp>‐<scp>ADMA</scp>‐<scp>NO</scp> pathway2016 · 44 citations
  4. 4Rosuvastatin Changes Cytokine Expressions in Ischemic Territory and Preserves Heart Function After Acute Myocardial Infarction in Rats2012 · 10 citations
  5. 5Rosuvastatin, a New HMG-CoA Reductase Inhibitor, Protects Ischemic Reperfused Myocardium in Normocholesterolemic Rats2003 · 65 citations