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April 1, 2003Journal of Cardiovascular Pharmacology

Rosuvastatin, a New HMG-CoA Reductase Inhibitor, Protects Ischemic Reperfused Myocardium in Normocholesterolemic Rats

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Why the study?

Does rosuvastatin improve cardiac function and reduce PMN adherence in isolated ischemic reperfused rat hearts?

Population

Normocholesterolemic rats; isolated hearts subjected to 20 min ischemia and 45 min reperfusion, perfused…

Comparison

Rosuvastatin administered 18 h before… vs 0.9% NaCl administered 18 h before…

Design

Preclinical

Follow-up

45 min (reperfusion phase)

Authors

YIYasuhiko IkedaLYLindon YoungALAllan M. Lefer

Discussion

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Overview

Does not support clinical use in reperfusion injury; leaves open pleiotropic cardioprotection for human translation studies.

Structured PICO

Does rosuvastatin improve cardiac function and reduce PMN adherence in isolated ischemic reperfused rat hearts?

P
Population
Normocholesterolemic rats; isolated hearts subjected to 20 min ischemia and 45 min reperfusion, perfused with polymorphonuclear leukocytes (PMNs)
I
Intervention
Rosuvastatin (0.25 or 1.25 mg/kg) administered 18 h before ischemia/reperfusion
C
Comparator
0.9% NaCl administered 18 h before ischemia/reperfusion
O
Outcome
Left ventricular developed pressure and the maximal rate of development of left ventricular developed pressure (+dP/dt(max))surrogate

Rosuvastatin attenuates PMN-induced cardiac contractile dysfunction in isolated ischemic reperfused rat hearts, suggesting cardioprotective effects independent of lipid lowering.

Cite This Study

Ikeda et al. (2003) studied this question.

synapsesocial.com/papers/6a7c351f4fcef545fadfabefhttps://doi.org/10.1097/00005344-200304000-00019
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Also Consider

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