Why the study?
Does simvastatin improve cardiac contractile function and reduce neutrophil-mediated injury in a rat model of myocardial ischemia-reperfusion?
Population
Normocholesterolemic isolated perfused rat heart model of ischemia and reperfusion injury perfused with…
Comparison
Simvastatin 25 micrograms/rat vs Vehicle
Design
Preclinical
Follow-up
65 minutes (20 minutes ischemia, 45 minutes reperfusion)
Authors
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Simvastatin may attenuate neutrophil-mediated reperfusion injury; hypothesis-generating in animals and requires clinical trials before any practice implications.
Does simvastatin improve cardiac contractile function and reduce neutrophil-mediated injury in a rat model of myocardial ischemia-reperfusion?
Simvastatin preserves cardiac contractile function and reduces leukocyte-endothelial cell interactions after myocardial ischemia-reperfusion in a cholesterol-independent manner.
Lefer et al. (1999) studied this question.
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