Why the study?
Does short-term simvastatin treatment reduce leukocyte-endothelium interaction and myocardial ischemia-reperfusion injury in apoE-deficient mice fed a high-cholesterol diet?
Population
Apolipoprotein E-deficient (apoE-/-) mice fed a high-cholesterol diet
Comparison
Simvastatin treatment for 18 hours vs Vehicle
Design
Preclinical
Follow-up
18 to 24 hours
Authors
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Hypothesis-generating for statin pleiotropy in hypercholesterolemic reperfusion injury; prospective human trials needed before clinical consideration.
Does short-term simvastatin treatment reduce leukocyte-endothelium interaction and myocardial ischemia-reperfusion injury in apoE-deficient mice fed a high-cholesterol diet?
Short-term simvastatin treatment exerts anti-inflammatory and cardioprotective effects against ischemia-reperfusion injury in hypercholesterolemic mice, independent of its lipid-lowering actions.
Scalia et al. (2001) studied this question.
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