June 1, 2001British Journal of PharmacologyOpen Access

A new HMG‐CoA reductase inhibitor, rosuvastatin, exerts anti‐inflammatory effects on the microvascular endothelium: the role of mevalonic acid

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Why the study?

Does rosuvastatin reduce thrombin-induced leukocyte-endothelium interactions in animal models?

Population

Rats (mesenteric microvasculature and aortic segments) and eNOS(-/-) mice

Comparison

Intraperitoneal administration of 0.5 and 1.25… vs Thrombin-stimulated controls without…

Design

Preclinical

Authors

TSTimothy J. StalkerThomas Jefferson University ALAllan M. LeferTH Köln - University of Applied Sciences RSRosario ScaliaTemple University

Discussion

Member takes

Implication

Hypothesis-generating for statin anti-inflammatory effects on endothelium; clinical translation requires prospective human studies.

Structured PICO

Does rosuvastatin reduce thrombin-induced leukocyte-endothelium interactions in animal models?

Population

Rats (mesenteric microvasculature and aortic segments) and eNOS(-/-) mice

Intervention

Intraperitoneal administration of 0.5 and 1.25 mg/kg rosuvastatin 18 hours prior to study

Comparator

Thrombin-stimulated controls without rosuvastatin, and rosuvastatin combined with mevalonic acid (25 mg/kg)

Outcome

Leukocyte rolling, adherence, and transmigration in the mesenteric microvasculature superfused with thrombinsurrogate

Rosuvastatin exerts anti-inflammatory effects on the microvascular endothelium by inhibiting leukocyte-endothelium interactions via a nitric oxide-dependent mechanism involving reduced mevalonic acid.

Cite This Study

Stalker et al. (2001) studied this question.

synapsesocial.com/papers/6a1eeb14d0800f8eb7c8dfa7 https://doi.org/10.1038/sj.bjp.0704070

Topics

Statin therapy

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