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April 25, 2026DiagnosticsOpen Access

Biomarker-Based Diagnosis and Risk Stratification in Sepsis-Associated Acute Kidney Injury: From Molecular Mechanisms to Multimarker Panels

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Authors

BPBreallan De Jesus Romero PájaroUniversidad Libre de ColombiaDSDiana Carolina Caicedo SanchezUniversidad Libre de ColombiaMLMichael Mario Vélez LoraUniversidad Libre de Colombia

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Implication

Narrative review synthesizes evidence on biomarkers to improve diagnosis and risk assessment in septic patients with AKI, suggesting implications for clinical practice.

Key Points

  • This review aims to explore the role of biomarkers in diagnosing and assessing risk in sepsis-associated acute kidney injury (SA-AKI).
  • Narrative review synthesizing current evidence on biomarkers relevant to SA-AKI including stress markers, tubular injury markers, and molecular signatures.
  • Discussion of temporal dynamics, performance estimates, and limitations of biomarker applications in sepsis.
  • Framework proposed for interpreting biomarkers in SA-AKI linked to pathophysiological windows.
  • Selected biomarkers show potential for short-term risk stratification and trajectory assessment in SA-AKI.
  • Evidence supports the integration of biomarkers with KDIGO criteria for improved clinical decision-making.
  • Prospective validation needed to confirm incremental value of biomarkers beyond existing models.

Cite This Study

Pájaro et al. (2026) studied this question.

synapsesocial.com/papers/69ec5a6b88ba6daa22dabf51https://doi.org/10.3390/diagnostics16091262
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Also Consider

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  1. 1Nephrologist-Performed Point-of-Care Ultrasound in Acute Kidney Injury: Beyond Hydronephrosis2022 · 9 citations
  2. 2Value of Serum Cystatin C Measurement in the Diagnosis of Sepsis-Induced Kidney Injury and Prediction of Renal Function Recovery2017 · 84 citations
  3. 3Acute Kidney Injury following Cardiopulmonary Bypass: A Challenging Picture2021 · 39 citations
  4. 4Canadian Association of Radiologists Guidance on Contrast Associated Acute Kidney Injury2022 · 56 citations
  5. 5Acute Kidney Injury in Patients with Liver Disease2022 · 68 citations