What does this research mean for the field?

Sepsis-associated acute kidney injury is a multifactorial, predominantly non-ischemic process driven by inflammatory dysregulation, microcirculatory dysfunction, and adaptive metabolic reprogramming, which requires advanced biomarkers for early risk stratification and targeted therapies. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize recent advances in the definition, pathophysiology, diagnostic biomarkers, preclinical models, and clinical management of sepsis-associated acute kidney injury.

September 3, 2026Journal of Intensive MedicineOpen Access

Translating the pathophysiology of sepsis-associated acute kidney injury: From bench to bedside

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To synthesize recent advances in the definition, pathophysiology, diagnostic biomarkers, preclinical models, and clinical management of sepsis-associated acute kidney injury.
Narrative review synthesizing mechanisms, preclinical models, and clinical evidence regarding sepsis-associated acute kidney injury.
Evaluation of diagnostic tools including the 2023 ADQI consensus and domain-specific biomarkers for tubular injury, cell cycle arrest, and endothelial dysfunction.
Appraisal of experimental animal models and investigational treatments such as cytokine removal, hemodynamic support, and mitochondrial therapeutics.
Pathophysiology has shifted from pure renal hypoperfusion to a complex interplay of inflammatory dysregulation, microvascular dysfunction, adaptive metabolic shutdown, and regulated cell death mechanisms such as pyroptosis and ferroptosis.
Multi-organ crosstalk along the lung–gut–heart–kidney axis substantially exacerbates renal dysfunction during severe sepsis.
Emerging mechanistic biomarkers (such as NGAL, KIM-1, TIMP-2·IGFBP7, and Angpt-2/Tie2) enable risk stratification earlier than traditional serum creatinine measurements, though clinical translation of novel therapeutics remains limited.

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Implication

Review uncovers multifaceted non-ischemic mechanisms in sepsis-associated acute kidney injury, highlighting barriers to clinical translation.

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a993600636c6408cfa7eb0b https://doi.org/10.1016/j.jointm.2026.08.005

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Implication

Review uncovers multifaceted non-ischemic mechanisms in sepsis-associated acute kidney injury, highlighting barriers to clinical translation.

Translating the pathophysiology of sepsis-associated acute kidney injury: From bench to bedside

Key Points

Discussion

Implication

Cite This Study

Translating the pathophysiology of sepsis-associated acute kidney injury: From bench to bedside

Key Points

Discussion

Implication

Cite This Study

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