Higher admission serum cortisol levels were independently associated with the presence of variant angina compared to patients with normal coronaries (OR 1.59).
Observational (n=192)
No
Are elevated serum cortisol levels associated with variant angina in patients undergoing coronary angiography for suspected ischemic chest pain?
Elevated serum cortisol levels during the acute phase are independently associated with variant angina, suggesting a potential role for stress-related neurohormonal pathways in coronary vasospasm.
Effect estimate: OR 1.59 (95% CI 1.12-2.24)
p-value: p=0.01
Variant angina (VA) is an important yet underexplored condition where mechanisms beyond atherosclerosis, including stress-related pathways, may contribute to vasospasm.We examined stress hormone profiles, with a focus on cortisol, in patients undergoing coronary angiography.Patients with VA showed consistently higher cortisol levels at admission and shortly after angiography compared with controls, even after adjustment for baseline factors.Although the small sample size and methodological limitations require cautious interpretation, these findings highlight an unmet need for better understanding of neurohormonal stress responses in VA and their potential clinical implications.
Lee et al. (Thu,) conducted a observational in Variant angina (n=192). Serum cortisol levels vs. Normal coronaries was evaluated on Variant angina diagnosis (multivariable logistic regression) (OR 1.59, 95% CI 1.12-2.24, p=0.01). Higher admission serum cortisol levels were independently associated with the presence of variant angina compared to patients with normal coronaries (OR 1.59).