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April 25, 2026International Journal of Molecular SciencesOpen Access

Altered Lipid Profile and Oxidative Stress During Pregnancy: Impact on the Fetus and Risk of Metabolic Disorders in Adulthood

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Authors

KJKristina JovanovićUniversity Children's Hospital, BelgradeMJMiljana Z. JovandaricDJDarko Jovanovic

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Implication

Review evaluates how maternal lipid metabolism influences fetal organ growth and metabolic risks.

Key Points

  • The review investigates the pathways connecting maternal lipid metabolism to fetal development and long-term health.
  • Mechanistic and translational studies were reviewed using databases such as PubMed and Scopus from 2000 to 2025.
  • Predefined keywords included lipid metabolism, oxidative stress, and perinatal outcomes.
  • Maternal dyslipidemia contributes to fetal organ hypertrophy and disrupts metabolic homeostasis.
  • Oxidative stress and epigenetic modifications are heightened by maternal lipid imbalances.
  • Enhanced metabolic disorder risks in neonates linked to maternal lipid and oxidative stress levels.

Cite This Study

Jovanović et al. (2026) studied this question.

synapsesocial.com/papers/69ec5b2388ba6daa22dacb87https://doi.org/10.3390/ijms27093744
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Also Consider

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  1. 1Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences2026 · 8 citations
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  3. 3The Interplay Between Oxidative Stress and Lipid Composition in Obesity-Induced Inflammation: Antioxidants as Therapeutic Agents in Metabolic Diseases2025 · 44 citations
  4. 4Adherence to the Mediterranean Diet in Pregnancy and Its Benefits on Maternal-Fetal Health: A Systematic Review of the Literature2022 · 65 citations
  5. 5Blood lipids influence DNA methylation in circulating cells2016 · 200 citations