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December 4, 2025AntioxidantsOpen Access

Oxidative Stress-Related Metabolomic Alterations in Pregnancy: Evidence from Exposure to Air Pollution, Metals/Metalloid, and Tobacco Smoke

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APAlica Pizent

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Overview

Review reports metabolomic alterations from oxidative stress due to air pollution and tobacco smoke in pregnancy, suggesting risks for non-communicable diseases.

Key Points

  • Maternal exposure to environmental stressors disrupts metabolomic pathways critical for fetal health, including those affecting amino acids and lipids.
  • Epidemiological studies indicate significant impacts from air pollution, particularly fine particulate matter, on lipid metabolism and antioxidant responses.
  • The metabolomic approach provides insights into metabolic disorders associated with oxidative stress from tobacco smoke exposure.
  • Identifying these pathways may aid in developing biomarkers and therapeutic strategies to mitigate non-communicable disease risk.

Cite This Study

Alica Pizent (2025) studied this question.

synapsesocial.com/papers/6930dc8aea1aef094cca2872https://doi.org/10.3390/antiox14121442
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Altered Lipid Profile and Oxidative Stress During Pregnancy: Impact on the Fetus and Risk of Metabolic Disorders in Adulthood2026
  2. 2Longitudinal Assessment of Oxidative Stress Biomarkers During Physiological Pregnancy and Their Relevance for Maternal Healthcare2026
  3. 3Perinatal Redox Dysregulation in Gestational Tobacco Exposure: Compartment-Specific Composite Indices and Their Association with Birth Outcomes—A Prospective Cohort Study2026
  4. 4Fetal development and the air pollution exposome: an integrative perspective of health pathways2025 · 5 citations
  5. 5Fetal development and the air pollution exposome: an integrative perspective of health pathways2025