What question did this study set out to answer?

This study aims to explore the effects of gestational tobacco exposure on redox indices and their association with adverse birth outcomes.

August 13, 2026AntioxidantsOpen Access

Perinatal Redox Dysregulation in Gestational Tobacco Exposure: Compartment-Specific Composite Indices and Their Association with Birth Outcomes—A Prospective Cohort Study

View Full Paper

Ask AI

Bookmark

Authors

Prospective cohort study finds tobacco exposure affects redox indices, influencing birth weight and preterm birth risk.

This study aims to explore the effects of gestational tobacco exposure on redox indices and their association with adverse birth outcomes.
Conducted a prospective cohort study with 66 maternal-neonatal dyads (24 smokers, 42 non-smokers) from Târgu-Mures.
Quantified six redox biomarkers in maternal and cord blood and derived composite redox indices (OSI, NSI, GRI).
Used multivariable regression to assess associations with preterm birth and low birth weight, applying FDR correction.
Tobacco exposure linked to a significant depletion of the Neonatal NSI (mean difference = −0.842; 95% CI: −1.567 to −0.117; p = 0.024).
Lower Maternal GRI and Neonatal NSI were associated with lower birth weight (aOR = 0.35) and higher odds of preterm birth (aOR = 0.52), both p < 0.05.
Maternal and neonatal nitrite levels were positively correlated (FDR-adjusted p = 0.002), while oxidized glutathione levels showed an inverse correlation (FDR-adjusted p = 0.001).

Simon-Szabó et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark