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This study aims to assess changes in oxidative stress markers and antioxidants throughout pregnancy trimesters.

June 30, 2026HealthcareOpen Access

Longitudinal Assessment of Oxidative Stress Biomarkers During Physiological Pregnancy and Their Relevance for Maternal Healthcare

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Longitudinal trial evaluates oxidative stress biomarkers in pregnant women, highlighting changes in antioxidant levels.

This study aims to assess changes in oxidative stress markers and antioxidants throughout pregnancy trimesters.
Longitudinal analysis of plasma levels during the first, second, and third trimester in 31 healthy non-smoking pregnant women.
Assessment of non-enzymatic antioxidants and oxidative stress markers, including malondialdehyde and protein carbonyls.
Statistical analyses using Friedman tests and Dunn’s post hoc comparisons with false discovery rate correction.
Vitamin A consistently decreased across all trimesters, showing a 20% reduction by third trimester.
α-tocopherol and γ-tocopherol levels increased significantly, with p<0.05 during gestation.
Markers of oxidative damage exhibited significant trimester-dependent increases, with malondialdehyde showing a 30% rise by third trimester.

Valachovičová et al. (2026) studied this question.

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