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April 26, 2026SHILAP Revista de lepidopterologíaOpen Access

Morphological and functional echocardiographic findings in pediatric patients diagnosed with hypermobile Ehlers-Danlos syndrome

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Authors

WVWalter VignaroliVilla Maria HospitalGMGioia MastromoroAgostino Gemelli University PolyclinicCPCarolina PutottoSapienza University of Rome

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Implication

Randomized trial demonstrates cardiac changes in pediatric patients with hypermobile Ehlers-Danlos syndrome, suggesting the need for monitoring.

Key Points

  • This study aims to evaluate the cardiovascular implications of hypermobile Ehlers-Danlos syndrome in children.
  • Evaluated 28 pediatric patients with hEDS and 28 matched healthy controls.
  • Utilized two-dimensional echocardiography, Doppler, TDI, and STE for analysis.
  • Conducted global longitudinal strain analysis to assess myocardial function.
  • 32% of hEDS patients showed mitral valve prolapse.
  • hEDS patients had significantly higher Z-scores for aortic root compared to controls.
  • Global longitudinal strain values were reduced in hEDS patients (p < 0.001) despite preserved left ventricular ejection fraction.

Cite This Study

Vignaroli et al. (2026) studied this question.

synapsesocial.com/papers/69edaa9b4a46254e215b3291https://doi.org/10.3389/fped.2026.1768520
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Also Consider

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