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April 26, 2026Frontiers in Aging NeuroscienceOpen Access

Integrated transcriptomic profiling combined with in vitro validation reveals the involvement of TMEM140 in the link between periodontitis and brain aging

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Authors

HZHaoran ZhaoHWHongtao WangWLWenhua Li

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Overview

Randomized trial shows TMEM140's involvement in brain aging linked to periodontitis, indicating potential therapeutic targets.

Key Points

  • This study aims to explore the molecular connections between periodontitis and brain aging, focusing on TMEM140.
  • Integrated transcriptomic analysis from GEO database for PD and AD datasets
  • Machine learning algorithms (RF, SVM, GLM, XGB) to identify key genes
  • In vitro experiments using inflammatory models in human gingival fibroblasts and neuron-like cells.
  • Seven common aging-related genes were identified between PD and AD including TMEM140, which was upregulated in PD and downregulated in AD.
  • TMEM140 knockdown in neuron-like cells led to increased injury, higher ROS production, and elevated inflammatory markers such as IL-1β and TNF-α.
  • These findings suggest that reduced TMEM140 increases neuron-like cells' vulnerability to inflammatory stress.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/69edaafc4a46254e215b3373https://doi.org/10.3389/fnagi.2026.1761218
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