Why the study?
To understand the characteristics of disease onset, special diagnosis, and main treatment methods for giant retroperitoneal dedifferentiated liposarcoma.
This case report demonstrates the successful short-term management of a giant retroperitoneal dedifferentiated liposarcoma using en bloc resection combined with multimodal adjuvant therapy.
Demonstrates feasibility of en bloc multivisceral resection in giant retroperitoneal liposarcoma; leaves open broader applicability pending larger studies.
This article presents a 60-year-old woman presented with a one-year history of abdominal distension, which acutely worsened over four days prior to admission. Imaging revealed a large retroperitoneal liposarcoma. Exploratory laparotomy identified a massive tumor (approximately 45×40×13 cm, weighing 8 kg) invading the left kidney, adrenal gland, adnexa, left hemicolon, and mesentery. En bloc resection was performed. Postoperative pathology combined with fluorescence in situ hybridization (FISH) testing demonstrated MDM2/CDK4 amplification, confirming dedifferentiated liposarcoma (DDLPS). The patient recovered well postoperatively and was discharged following adjuvant radiotherapy (IMRT; 50 Gy in 25 fractions), chemotherapy (AD regimen), and immunotherapy (sintilimab).Through this case, we mainly understand the characteristics of the disease onset, special diagnosis, and main treatment methods.
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Xu et al. (2026) studied this question.
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