Key result
Reductive surgery for giant retroperitoneal liposarcoma provides temporary relief before fatal 11-month disease progression.
Why the study?
Retroperitoneal liposarcoma with both a dedifferentiated subtype and a diameter >30 cm is rare, with few published reports.
Case Report (n=1)
No
Highlights a rare case of a giant retroperitoneal dedifferentiated liposarcoma mimicking ovarian cancer, emphasizing the diagnostic challenge and poor prognosis.
Answers are grounded in this paper and cite their sources.
May afford short-term palliation in giant retroperitoneal dedifferentiated liposarcoma; single case leaves open survival benefit of surgery.
Retroperitoneal liposarcoma is a rare tumor, and its dedifferentiated subtype and a larger diameter are associated with a poor prognosis. However, there are few reports of retroperitoneal liposarcomas, both with a dedifferentiated subtype and a diameter of >30 cm. We report a case of a giant retroperitoneal liposarcoma with a dedifferentiated subtype. A 78-year-old woman presented to our hospital with abdominal distension and loss of appetite. Computed tomography and magnetic resonance imaging findings revealed a 35-cm-diameter solid tumor in the peritoneal cavity. CA125 (64.8 U/mL) and HE4 (229.0 pmol/L) were elevated preoperatively raising suspicion for ovarian malignancy. However, intraoperative findings revealed that the tumor originated in the retroperitoneal cavity. Reductive surgery for the tumor and partial resection of the sigmoid colon and left ureter were performed, and pathological examination confirmed a retroperitoneal dedifferentiated liposarcoma. Although her symptoms improved postoperatively, she died 11 months after surgery due to disease progression.
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Tani et al. (2022) conducted a case report in Giant retroperitoneal dedifferentiated liposarcoma (n=1). Reductive surgery and partial resection of the sigmoid colon and left ureter was evaluated. Reductive surgery for a 35-cm giant retroperitoneal dedifferentiated liposarcoma provided temporary symptom relief, but the patient died 11 months postoperatively due to disease progression.
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