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April 26, 2026CureusOpen Access

Myositis-Myasthenia Overlap Syndrome After Immune Checkpoint Inhibitor Treatment: A Case Report

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Authors

CAChristopher S. AwadJRJack C RedickSSSydney Scheel

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Overview

Case report finds ICI-related myositis-myasthenia gravis overlap in elderly man, highlighting diagnostic challenges.

Key Points

  • The aim is to describe a case of myositis-myasthenia gravis overlap syndrome following immune checkpoint inhibitor treatment.
  • Case report of a 77-year-old man treated with immune checkpoint inhibitors for cancer.
  • Initial diagnosis was focused on non-ST-elevation myocardial infarction; subsequent symptoms led to further evaluation.
  • Treatment included high-dose intravenous methylprednisolone and empiric plasmapheresis.
  • The patient developed progressive generalized weakness and respiratory compromise after immunotherapy.
  • Transient improvement was observed with intravenous steroids, but deterioration occurred with oral corticosteroids.
  • Post-plasmapheresis, the patient's neuromuscular strength and respiratory status gradually improved.

Cite This Study

Awad et al. (2026) studied this question.

synapsesocial.com/papers/69edab424a46254e215b3521https://doi.org/10.7759/cureus.107600
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