What question did this study set out to answer?

To characterize the clinical presentation, emergency department management, and outcomes of patients presenting with an overlap syndrome of myasthenia gravis, myositis, and myocarditis linked to immune checkpoint inhibitor therapy.

March 8, 2021The American Journal of Emergency MedicineOpen Access

Immune checkpoint inhibitor-associated myasthenia gravis, myositis, and myocarditis overlap syndrome

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To characterize the clinical presentation, emergency department management, and outcomes of patients presenting with an overlap syndrome of myasthenia gravis, myositis, and myocarditis linked to immune checkpoint inhibitor therapy.
Retrospective electronic medical record review conducted between September 1, 2016, and March 9, 2020.
Identified all patients (N=7) with the triad of myasthenia gravis, myositis, and myocarditis who presented to the emergency department.
The majority of patients were female, received programmed cell death-1 inhibitors, presented with abnormal vital signs, and exhibited ptosis, diplopia, dyspnea, and fatigue.
All patients received systemic steroids alongside additional immunomodulators, most required supplemental oxygen and prolonged hospitalization, and two patients died.

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Implication

Retrospective review reveals high mortality from checkpoint inhibitor overlap syndrome in emergency patients, highlighting the need for prompt recognition and high-dose steroids.

Cite This Study

Lipe et al. (2021) studied this question.

synapsesocial.com/papers/6a9240e2a592a3eaf2384048 https://doi.org/10.1016/j.ajem.2021.03.005

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Implication

Retrospective review reveals high mortality from checkpoint inhibitor overlap syndrome in emergency patients, highlighting the need for prompt recognition and high-dose steroids.

Immune checkpoint inhibitor-associated myasthenia gravis, myositis, and myocarditis overlap syndrome

Key Points

Discussion

Implication

Cite This Study

Immune checkpoint inhibitor-associated myasthenia gravis, myositis, and myocarditis overlap syndrome

Key Points

Discussion

Implication

Cite This Study

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