D-18 | Sex Differences in Clinical Outcomes After Percutaneous Coronary Intervention in Young Adults (≤45 Years)

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Acute myocardial infarction (AMI). Intervention: Male sex vs. Female sex. Primary outcome: Out-of-hospital death (home, emergency department/outpatient, or dead-on arrival).

Q: What does this research mean for the field?

Among U.S. acute myocardial infarction deaths, men experience a significantly higher proportion of out-of-hospital deaths compared to women (41.4% vs 33.1%), whereas women more frequently die in long-term care facilities. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

FNU Anamika; Sakshi Dixit; JUMA BIN FIROS; Kamleshun Ramphul; N Kumar; Gurjot Singh

doi:10.1016/j.jscai.2026.104887

April 1, 2026Journal of the Society for Cardiovascular Angiography & InterventionsOpen Access

D-18 | Sex Differences in Clinical Outcomes After Percutaneous Coronary Intervention in Young Adults (≤45 Years)

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Why the study?

Population-level patterns in acute myocardial infarction mortality and location of death by sex remain incompletely characterized despite advances in systems of care.

Are there sex differences in age-adjusted mortality rates and location of death among U.S. patients dying from acute myocardial infarction?

Key Points

The study aims to explore the differences in clinical outcomes and locations of death due to acute myocardial infarction between sexes in young adults.
Analyzed U.S. acute myocardial infarction (AMI) deaths from 1999-2020 using CDC WONDER.
Calculated age-adjusted mortality rates by sex and year, focusing on known places of death.
Classified place of death as home, emergency department, inpatient facility, nursing care, or hospice.
Overall age-adjusted mortality rates were higher in men than women, with declining trends detected in both groups.
Men had a 41.4% out-of-hospital death rate compared to 33.1% in women, across all urbanization categories.
Women had a higher percentage of deaths occurring in nursing or long-term care facilities.

Study Design

Type

Observational

Structured PICO

Are there sex differences in age-adjusted mortality rates and location of death among U.S. patients dying from acute myocardial infarction?

P

Population

U.S. AMI deaths (ICD-10 I21-I22) from 1999-2020

I

Intervention

Male sex

C

Comparator

Female sex

O

Outcome

Age-adjusted mortality rates (AAMRs) and place of deathhard clinical

Main Result

Absolute Event Rate: 41.4% vs 33.1%

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Men experience higher AMI mortality and out-of-hospital deaths compared to women, highlighting persistent sex differences in AMI outcomes and care pathways.

Abstract

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Discussion

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Cite This Study

Anamika et al. (2026) conducted an observational in Acute myocardial infarction (AMI). Male sex vs. Female sex was evaluated on Out-of-hospital death (home, emergency department/outpatient, or dead-on arrival).

synapsesocial.com/papers/69edab424a46254e215b3565 https://doi.org/10.1016/j.jscai.2026.104887

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D-18 | Sex Differences in Clinical Outcomes After Percutaneous Coronary Intervention in Young Adults (≤45 Years)

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

D-18 | Sex Differences in Clinical Outcomes After Percutaneous Coronary Intervention in Young Adults (≤45 Years)

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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