F-67 | Trends and Disparities in Ischemic Heart Disease Mortality Among Older Adults With Hypertensive Heart Disease in the United States, (1999–2023)

Q: What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Heart and liver transplant rejection (n=230). Intervention: Donor-derived cell-free DNA (dd-cfDNA). Primary outcome: Diagnostic accuracy for acute cellular rejection, antibody-mediated rejection, and overall graft rejection (Sensitivity 0.88, 95% CI 0.80-0.93).

Q: What does this research mean for the field?

Donor-derived cell-free DNA demonstrates high diagnostic accuracy for detecting heart transplant rejection (AUC 0.94) and moderate accuracy for liver transplant rejection (AUC 0.85). Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Muhammad Usama; Muhammad Ali; Anas Nasir; Sadia Ghafur; Dania Hussain; Haider Imran; Saif ur Rahman; Muhammad Saad Bin Arshad Arain

doi:10.1016/j.jscai.2026.105179

April 1, 2026Journal of the Society for Cardiovascular Angiography & InterventionsOpen Access

F-67 | Trends and Disparities in Ischemic Heart Disease Mortality Among Older Adults With Hypertensive Heart Disease in the United States, (1999–2023)

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Key Points

This research explores trends and disparities in mortality rates due to ischemic heart disease among older adults with hypertensive heart disease in the United States from 1999 to 2023.
Analyzed mortality trends in older adults with hypertensive heart disease.
Utilized national health databases to assess ischemic heart disease mortality rates over the specified years.
Statistical analyses included calculating mortality rates and identifying disparities among different demographics.
Identified significant increases in ischemic heart disease mortality rates among older adults with hypertensive heart disease.
Disparities in mortality were evident across different racial and socioeconomic groups.
Statistical analysis showed a concerning trend in mortality rates from 1999 to 2023.

Study Design

Type

Meta-Analysis (n=230)

Structured PICO

P

Population

1,813,023 older adults (aged ≥65 years) in the United States who died with ischemic heart disease (IHD) as an underlying cause and hypertensive heart disease (HHD) as a contributing cause between 1999 and 2023.

O

Outcome

Age-adjusted mortality rates (AAMR) per 100,000 and average annual percent change (AAPC) for IHD-related deaths in older adults with HHD.hard clinical

Main Result

Effect estimate: Sensitivity 0.88 (95% CI 0.80-0.93)

Implication

While overall IHD mortality in older adults with HHD has remained stable since 1999, significant disparities exist, with increasing mortality rates observed in men, Hispanic/Latinos, and the Western US region.

Discussion

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Cite This Study

Usama et al. (2026) conducted a meta-analysis in Heart and liver transplant rejection (n=230). Donor-derived cell-free DNA (dd-cfDNA) was evaluated on Diagnostic accuracy for acute cellular rejection, antibody-mediated rejection, and overall graft rejection (Sensitivity 0.88, 95% CI 0.80-0.93).

synapsesocial.com/papers/69edab424a46254e215b35f1 https://doi.org/10.1016/j.jscai.2026.105179

Topics

Heart transplantation

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F-67 | Trends and Disparities in Ischemic Heart Disease Mortality Among Older Adults With Hypertensive Heart Disease in the United States, (1999–2023)

Key Points

Study Design

Structured PICO

Main Result

Implication

Discussion

Cite This Study

Topics

F-67 | Trends and Disparities in Ischemic Heart Disease Mortality Among Older Adults With Hypertensive Heart Disease in the United States, (1999–2023)

Key Points

Study Design

Structured PICO

Main Result

Implication

Discussion

Cite This Study

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