C-63 | Burden of Anemia on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement: A Nationwide Analysis

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Transcatheter Aortic Valve Replacement. Intervention: Anemia vs. Absence of anemia. Primary outcome: In-hospital mortality (AOR 1.22, 95% CI 1.03-1.45, p=0.024).

Emmanuel Olumuyide; Abdulkareem Lukan

doi:10.1016/j.jscai.2026.104799

April 1, 2026Journal of the Society for Cardiovascular Angiography & InterventionsOpen Access

C-63 | Burden of Anemia on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement: A Nationwide Analysis

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Why the study?

Does anemia increase in-hospital mortality and adverse outcomes in adult patients undergoing TAVR?

Key Points

To assess the association between pre-existing or procedural anemia and in-hospital mortality and procedural complications in adult patients undergoing transcatheter aortic valve replacement.
Adult hospitalizations undergoing transcatheter aortic valve replacement were stratified by the presence or absence of anemia.
Multivariable logistic regression was performed to estimate adjusted odds ratios for in-hospital mortality and key secondary outcomes, controlling for demographics, comorbidity burden, and hospital characteristics.
Compared with non-anemic patients, those with anemia had significantly higher in-hospital mortality (0.95% vs 2.23%; AOR 1.22, 95% CI 1.03–1.45, p=0.024).
Anemia was associated with increased risks of postprocedural bleeding (1.21% vs 3.87%; AOR 2.94, 95% CI 2.56–3.39, p<0.001) and cardiogenic shock (1.14% vs 3.76%; AOR 1.69, 95% CI 1.43–1.99, p<0.001).
Patients with anemia had higher rates of cardiac arrest (0.63% vs 1.49%; AOR 1.55, 95% CI 1.25–1.93, p<0.001) and need for mechanical circulatory support (0.05% vs 1.50%; AOR 1.95, 95% CI 1.49–2.57, p<0.001).

Study Design

Type

Observational

Multicenter

Yes

Structured PICO

Does anemia increase in-hospital mortality and adverse outcomes in adult patients undergoing TAVR?

P

Population

Adults hospitalized for transcatheter aortic valve replacement, stratified by the presence of anemia, evaluated for in-hospital outcomes.

E

Exposure

Presence of anemia

C

Comparator

Absence of anemia (non-anemic patients)

O

Outcome

In-hospital mortalityhard clinical

Main Result

Odds Ratio: 1.22 (95% CI 1.03–1.45)

Absolute Event Rate: 2.23% vs 0.95%

p-value: p=0.024

Implication

Anemia is independently associated with higher in-hospital mortality, bleeding, and hemodynamic compromise in patients undergoing TAVR.

Abstract

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Discussion

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Cite This Study

Olumuyide et al. (2026) conducted an observational in Transcatheter Aortic Valve Replacement. Anemia vs. Absence of anemia was evaluated on In-hospital mortality (AOR 1.22, 95% CI 1.03-1.45, p=0.024).

synapsesocial.com/papers/69edab814a46254e215b3765 https://doi.org/10.1016/j.jscai.2026.104799

Topics

Heart failure

HFrEF treatment

SGLT2 inhibitors in heart failure

HFpEF management

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C-63 | Burden of Anemia on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement: A Nationwide Analysis

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

Topics

C-63 | Burden of Anemia on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement: A Nationwide Analysis

Key Points

Study Design

Structured PICO

Main Result

Implication

Abstract

Discussion

Cite This Study

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