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April 1, 2026HLA

Identification of the Novel HLA‐A*33:278 Allele in a Chinese Individual by Sanger Dideoxy Nucleotide Sequencing

Dongmei Li Caifeng Long Yujie Wen Chengyan Fan Yanjun Jia

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Key Points

To identify and characterize the novel HLA-A*33:278 allele.
Utilized Sanger dideoxy nucleotide sequencing to analyze HLA alleles.
Focused on nucleotide substitution in codon 185 in exon 4.
Compared newly identified allele with HLA-A*33:03:01:01.
Discovered a novel allele, HLA-A*33:278, differing from HLA-A*33:03:01:01 by one nucleotide.
The nucleotide substitution occurred at codon 185 in exon 4.

Implication

Identification of a novel HLA-A*33:278 allele in a Chinese individual, suggesting genetic diversity in HLA typing.

Abstract

The HLA‐A*33:278 allele differs from HLA‐A*33:03:01:01 by one nucleotide substitution in codon 185 in exon 4.

Discussion

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69edab814a46254e215b383e https://doi.org/10.1111/tan.70735

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