October 5, 2025HLA

The Novel HLA‐C*08:294 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual

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The HLA-C*08:294 allele is identified through sequencing techniques, showing genetic variations.
The only difference between HLA-C*08:294 and HLA-C*08:01:01:01 is a single nucleotide change in exon 3.
Understanding this allele can aid in genetic research and enhance knowledge of immune responses.
This discovery was made in a Chinese individual, suggesting regional genetic diversity in HLA alleles.

Implication

This report uncovers the HLA-C*08:294 allele, differing by a nucleotide change from HLA-C*08:01:01:01, indicating possible genetic diversity.

HLA‐C*08:294 allele differs from HLA‐C*08:01:01:01 by a single non‐synonymous nucleotide change in exon 3.

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Gao et al. (2025) studied this question.

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This report uncovers the HLA-C*08:294 allele, differing by a nucleotide change from HLA-C*08:01:01:01, indicating possible genetic diversity.

HLA‐C*08:294 allele differs from HLA‐C*08:01:01:01 by a single non‐synonymous nucleotide change in exon 3.