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April 26, 2026BMC SurgeryOpen Access

Predictive value of biochemical markers and clinical scoring systems for outcomes in nonagenarians and centenarians admitted to the ICU after cholecystectomy for acute cholecystitis: a binational multicenter analysis

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Authors

JSJe Min SuhJLJerry LimNRNattaya Raykateeraroj

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Overview

Retrospective analysis identifies clinical predictors of mortality in nonagenarians after cholecystectomy, highlighting the need for improved risk stratification.

Key Points

  • This study aims to identify predictors of mortality and resource use in ICU patients aged 90 and older after cholecystectomy for acute cholecystitis.
  • Retrospective cohort study using data from the Australian and New Zealand Intensive Care Society Adult Patient Database (2010–2024)
  • Assessment of predefined clinical and biochemical predictors for 378 patients aged ≥ 90 years admitted to ICU after cholecystectomy
  • Outcomes analyzed included 1-year mortality, ICU length of stay, and 30-day mortality utilizing logistic regression and AUROC analyses.
  • 1-year mortality in ICU patients was 17.7%, with significant mortality rates at other time points (ICU: 1.9%, 30-day: 7.9%)
  • Higher APACHE III and serum urea were independently associated with 1-year mortality, with urea providing the best discrimination among biochemical markers (AUROC 0.71)
  • High-risk groups identified by APACHE III and urea thresholds displayed substantially higher 1-year mortality compared to low-risk groups.

Cite This Study

Suh et al. (2026) studied this question.

synapsesocial.com/papers/69edabdf4a46254e215b3c59https://doi.org/10.1186/s12893-026-03775-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictive Ability of Preoperative Multidomain Risk Stratification for Inpatient Outcomes in Older Patients With Acute Cholecystitis Undergoing Cholecystectomy ( <scp>PRIOC</scp> ): Retrospective Prognostic Study2026
  2. 2Prognostic performance of clinical scores and biomarkers in nonagenarians after TAVR requiring ICU admission2026
  3. 3Predictors of Mortality in Surgical Patients Admitted to a Tertiary Intensive Care Unit2025 · 2 citations
  4. 4Predictors of Mortality in Surgical Patients Admitted to a Tertiary Intensive Care Unit2025
  5. 5MANagement of Gallstone disease in the Older patient (MANGO): clinical and quality of life outcomes from a prospective multicentre cohort study2026