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April 26, 2026Organic Chemistry Frontiers0 citations

The lateral lithiation of pyrazoles: direct, transition-metal-free access to pyrazolopyridinones and pyrazolopyranones

KJKaijie JiJAJason AnKRKyle W. Rugg

Key Points

  • This research aims to explore a novel method for synthesizing pyrazolopyridinones and pyrazolopyranones.
  • Utilized lateral lithiation of amidopyrazoles for synthesis.
  • Employed nitriles and esters as reactants for producing pyrazolopyridinones and pyrazolopyranones, respectively.
  • Ensured the process is transition metal-free for simplified reactions.
  • Successfully synthesized pyrazolopyridinones and pyrazolopyranones using the transition metal-free approach.
  • Achieved efficient modular synthesis, enhancing the speed and flexibility of chemical processes.

Abstract

Lateral lithiation of amidopyrazoles enables an expedient, modular, transition metal-free synthesis of pharmaceutically relevant pyrazolopyridinones and pyrazolopyranones via reaction with nitriles or esters, respectively.

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Cite This Study

Ji et al. (2026) studied this question.

synapsesocial.com/papers/69edac2e4a46254e215b3f24https://doi.org/10.1039/d6qo00305b
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