Randomized trial examines BMI-SDS outcomes in girls with central precocious puberty, indicating weight changes are not sustained.
Key Points
The study aims to evaluate the changes in BMI-SDS during GnRHa therapy in girls with idiopathic central precocious puberty and their final adult height.
Followed 150 girls diagnosed with idiopathic central precocious puberty through their final adult height.
Measured BMI SDS at treatment end compared to baseline.
Analyzed associations between baseline BMI SDS and changes in BMI SDS.
BMI SDS did not show a sustained increase at final height across different baseline weight groups.
Baseline BMI SDS was identified as the key independent factor influencing BMI SDS changes.
Lower baseline BMI SDS predicted greater increases in BMI SDS at the end of treatment.