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This review investigates the connection between T cell senescence and aging, emphasizing potential therapeutic interventions.

Senescence of T cells and organ aging

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Review identifies strategies to address T cell aging-related issues in preventing diseases and promoting health.

This review investigates the connection between T cell senescence and aging, emphasizing potential therapeutic interventions.
Analyzed recent preclinical studies in murine models regarding T cell immunosenescence interventions.
Examined early-stage human clinical studies on caloric restriction and mTOR inhibition.
Discussed interventional strategies such as CAR-T cells and MSC therapy in addressing age-related diseases.
Modulation of T cell senescence showed promise in reducing age-related diseases in preclinical models.
Interventions like caloric restriction and low-dose mTOR inhibition demonstrated potential health benefits in early human studies.
T cell involvement in Alzheimer’s disease highlights a dual role in disease progression and protection.

Ohyagi et al. (2026) studied this question.

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